Of course it would be 'Atlasia 2', as applying similar offices helps with familiarity (and no point reinventing the wheel) Hopefully it could run alongside Atlasia, with people involved in both as very similar or indeed very different characters.
One thing that could be done easier than in Atlasia would be to have NPC's of some sort if there's a shortage of people for some positions or something.
A couple.
One very important (perhaps the most important) thing would be to establish a few boundaries over timescale (so the game would end at the onset of the Second World War, say), which is perhaps obvious, but... there's also a need to eliminate the use of hindsight (especially important as regards the actions of our "Hoover" actually) and of "obvious" fixes to the Depression dreamed up by academics writing decades later.
I think great care has to be taken over the impact of a few individuals over the course of history; most events that happend in real life would have to happen here as well, else things would get silly.
I'm not suggesting that in a killjoy way, quite the reverse actually.