In any other year, yes. Sexual harassment allegations were what sunk Herman Cain when he was the frontrunner for a week. No other candidate was able to turn his supporters into the kind of cult that Trump lovers are.
That's not really an apples to apples comparison though, since Cain's sexual harassment problems came up in the primary while Trump's pussygate came up late in the GE campaign.
Voters' allegiances to any particular candidate tend to be tenuous during the primary campaign, since there are multiple candidates of the same party to choose from. But in the GE? Republican voters would have been unlikely to jump ship on their nominee in favor of Hillary Clinton over sexual harassment regardless of whether the nominee was Trump or someone else.