This will likely happen the next time a Democrat wins the Presidency, due to demographics. I think Republicans will be in the wilderness for at least a few cycles before they change significantly enough to win a Presidential election again.
I can see it happening,but I think the GOP will rebound in the 2030s.
I can see a D 2020/2024/2028 or a D 2024/2028/2032
Then DeSantis or some other Republican wins.
Also if Hispanic immigrants "assimilate" to American culture and live a "white cultural type", Democrats may be upset.