Its certainly possible. If Obama gets reelected though. You would likely face a blowotu againts the Dems in 2014 in the Senate (so a possible strong majority from 2012 could reach 60) and regaining the House.
I think it would be premature to predict the results of the 2014 House elections. As for the Senate, yes the Republicans would be almost certain to have a majority after the 2014 elections, but I don't know about 60.
In any case, the chances of progressive legislation passing the Senate in the next 6 years are virtually zilch. Great job, Obama.