Lot of Republican-held marginal seats that were shored up this year.
The only marginal Republican seats that were put out of reach for Democrats are NC-02, TN-08, OH-01, OH-15, IN-09, NJ-07, and maybe PA-03. The rest are still very winnable for Democrats.
I'd add SC-05 to that list of marginal seats that were made safe. Without redistricting, Mulvaney might have been a vulnerable freshman, if he faced a quality Democratic opponent (which sadly are hard to come by in this state as one-party rule is never good, no matter which party rules). Not that the 2010 elections changed much here. Possibly the Republicans would have made the 5th a bit more Republican to make certain they would defeat Spratt it he had survived for one last term. But a 6-1 redistricting plan was a foregone conclusion.
It was only made about two points more Republican. Vincent Shaheen would have made it a real race against Mulvaney.
Spratt hung on as long as he did solely because he was an incumbent.
Even without redistricting, Sheheen was likely to have been looking forward to a rematch with Haley. Senatorial and Gubernatorial elections are on alternating 4 year cycles, so he can run for Governor without ever risking his Senate seat.