So did Wauquiez and the hard-right take over LR? Since there aren't meaningful differences with Macron on economics they're probably going to compete on immigration/integration/identity. Have there been any polls on the 2022 presidential election? It's premature but it would be interesting to see how Macron's unpopularity affects his scores.
He will win in December, with a strong right-wing policy on identity and immigration but he faces a possible revolt inside LR which could split the party (this is a threat from Pécresse for exemple) and to avoid that he tries to soften his stances on some issue (like same-sex marriage for exemple).
Who might be main oponent of Wauquiez? As far as I know the deadline for declaring participation is until beginning of October so not that much time - probably most of the big names are already known.