Assuming a Clinton Presidency, there are three different tiers of Senate Races in 2018.
Tier 1 are Red State Dems who the GOP has the best shot of beating. West Virginia, Indiana, Missouri, Montana, North Dakota. If I had to list their vulnerability, I'd do it in this order:
- Manchin, because West Virginia. (I'm slightly more optimistic than IceSpear, but juuust barely)
- Heitkamp, because of ND's rightward pull in the past few years.
- McCaskill. She's a talented politician and a moderate, but she's in a red state and barely won n 2006 and got a lucky break in 2012.
- Donnelly. Close call between him and McCaskill over who's more vulnerable, but I put Donnelly here because Indiana likes its split tickets more than other states.
- Montana. The MT Dems are a fine institution, certainly better than other red state Dem parties. Tester's still vulnerable, but not as much so as the four Senators above him.
After that is Tier 2, consisting of Ohio, Florida, Virginia, Pennsylvania, Maine, and Wisconsin. IIRC, (leaving out Maine) all of these Democratic Senators outperformed Obama, but they're still swing-state Dem Senators who would be prime pickup targets if not for Tier 1. They're probably relieved most of the fighting is going to be in Tier 1, which would leave little GOP resources for these states. They probably stay Dem if the midterm is a normal election year, but could flip GOP in a bloodbath.
Except Virginia. Warner survived 2014, as long as Kaine's replacement is decent they'll be okay. (Virginia would actually be the least safe of the Tier 2 states for Dems, alongside maybe Wisconsin, because the other Tier 2 states have 2-term Dem Senators)
Maine only flips if it's a divided 3-way race, and even then, King is probably fine.
There's also Tier 3: Arizona, Nevada, and Texas. Arizona was close in 2012, and Carmona ran ahead of Obama. Heller outran Romney in 2012, but Nevada's also known for the Reid Machine so maybe the Dems can mount a comeback here. A win in either state could offset a loss in a Tier 1 State and keep the GOP Majority narrow. But, well, these states are more then likely not going to flip.
Texas is only here because Democrats, and Lindsey Graham, salivate over the possibility of unseating Ted Cruz.
Edit: Going to make six different predictions based on these tiers. The new Senates would be based on a 2016 election that went as 538's Polls-Plus forecast characterised it on 10/17/2016, so D+5, 51/49.
1: Republican Bloodbath. GOP Pickups in every Tier 1 and 2 state: West Virginia, Indiana, Missouri, Montana, North Dakota, Ohio, Florida, Virginia, Pennsylvania, Maine, and Wisconsin. King doesn't even have to lose, he just has to change the party he caucuses with. That would be R + 11, enough to turn a 51 seat Dem Majority into a 60 seat, Fillibuster-Proof, Republican majority.
2. Republican Mauling. GOP Pickups in every Tier 1 state, and the Tier 2 states with 1st Term Dems: West Virginia, Indiana, Missouri, Montana, North Dakota, Virginia, Wisconsin, and possibly Maine. R + 8, resulting in a 57/43 GOP majority.
3. Republican Gut Punch. GOP Pickups in every Tier 1 State, but only in Tier 1 States: West Virginia, Indiana, Missouri, Montana, North Dakota. R + 5. The resulting Senate would be a 54/46 GOP Majority, exactly where we are now.
4. Republican Flesh Wound. GOP Pickups only in the most vulnerable Tier 1 States: West Virginia, North Dakota, and one of Indiana or Missouri. R + 3, new Senate would be a 52/48 GOP Majority, and an RSCC Chair would probably be out of a job.
5. Republican Laughingstock. GOP Pickup in only one of West Virginia or North Dakota, Democratic Pickup in one of Nevada or Arizona. +0, 51/49 Senate again, everybody laughs at the GOP.
6. Democratic Wet Dream. No GOP Pickups. Democratic Pickups in Arizona, Nevada, and possibly Texas. New Senate would be a 54/46 Democratic Majority that lasts until the alarm wakes Chuck Schumer up in the morning.