I don't think Republicans can win CO ever, state level or national level. It's just a non-stop target that Democrats don't want to give up for some odd reason. The GOP in CO needs to get its act together or it's another California.
I think a better comparison is Oregon. Denver has become the new Portland and the rest of the state is also becoming more democratic. The University of the Colorado is one of the most liberal universities in the country and I'm sure a large % of Colorado's population went to school there.