Well, the Democratic voters support single-payer and Hickenlooper fought hard against the single-payer ballot initiative. He's not going anywhere. Maybe he should run as a Republican.
If Hickenlooper does poorly, this won't be the reason. The state ballot initiative was massively flawed, both major parties came together to oppose it, and the people of the state voted against it 21/79. Even famously liberal Boulder County rejected it 38/62.
Sounds a lot like the Ohio marijuana abortion of a ballot measure.