There would have been San Diego suburbs in the area, that's for sure. But no real reason to think that there would have been a city called Tijuana, nor that its core area would have been anywhere near where it is now. Tijuana's one and only reason to exist, at least originally, is the presence of the border. There would have been a Mexican city wherever the border would have passed.
...which would also be spilling north of the border. All the Mexican border cities do. That was the logic I was using. (Tijuana would be where it is even if there were somehow no San Diego... the port got filled in by an earthquake or whatever... it's as much a suburb of LA as of San Diego.)