As I noted in another thread on this board, Democrats enjoy structural advantages for the 2010 Congressional elections, but, Republicans have structural advantages in the 2010 state elections as:
A. There are more Governor seats held by Democrats up for election, and
B. More state legislative seats held by Democrats up for election.
So, while Republican gains in the Senate may be minimal and in the U.S. House relatively small, gains in Governors and state legislators will probably be substantial.
This is particularly significant for redistricting for the 2012 - 2020 elections (which is still done by the state legislatures in most states).
The governorship gains for Republicans wont be that big. They are probably favored to pick up Oklahoma, Tennessee, and Kansas and Wyoming as well if Freudenthal cant run for another term(many suspect he will be able to). Pennsylvania and Michigan are pure tossups. Democrats are favored to pick up Hawaii, Rhode Island, and California. The likely scenario is Republicans picking up a net of two or three governorships.