I definitely would have voted for Wilkie. He was far from an isolationist, was actually fairly progressive for his time, and had a proven success record as a businessman. Plus, frankly after the recession of 1937 and other disasters (e.g. court packing) I wouldn't have trusted him to solve the country's problems either. He really didn't deserve a second term, let alone a third IMO.
Whether we like the man or not, I find it ludicrous for a person 71 years into the future to argue that FDR did not deserve a second term when he got 60.8% of the vote and won 523 out of 531 electoral votes. Even Reagan's 1984 win over Mondale and Nixon's 1972 win over McGovern were not as comprehensive a victory.