Some of the issues in the OP like LGBT were not relevant in 1988, and some of those that were like abortion did not drive the electorate the way they do today. Global warming was a decade away from the national debate and Appalachian coal country was still with the Dems.
Issues that are associated with the Christian right really started to surface in the 1992 election after the Murphy Brown speech by Quayle (which proved to be ahead of its time in terms of mobilizing that part of the electorate). In 1988 it was an issue that only affected a small part of the electorate concerned about judicial appointments, particularly SCOTUS. Reagan spoke to the issue in a way that impressed that part of the electorate, but basically took no action so few voters had it on their radar.
