No. By the very nature of things, any federal law that's not based in the constitution is null and of no affect. A nullification act is just an officail acknowledgement of it.
There must be a method for deciding whether a law is constitutional or not. It is best that we leave such decisions to the (theoretically at least) impartial judiciary who have spent a life time studying the Constitution as opposed to the inherently partisan state legislatures.
Lunar rightly points out that State Legislatures are not bodies of Constitutional experts, they are by definition partisan bodies. If we start allowing partisan bodies to decide what the Constitution means as you suggest, then we will arrive at the situation you most fear - partisans making up what they think the Constitution should be.
Your logic is total bollocks and arrives at a conclusion that opens the United States to anarchy with 50 separate interpretations of the same federal law.
You are free to disagree with me and the Constitutional experts as to what the Constitution says, and I'll happily go round for round with you on many issues, you never know, I might end up agreeing with you.
For the record, my opinion
Privacy - right is inherent in the Constitution
Abortion - right is not a reasonable extrapolation from privacy, but is protected under right to life when health or life of mother is threatened. The federal government has no authority to legislate on this matter, only the States do.
If you want me to justify either of those, feel free.