https://www.latimes.com/opinion/la-ol-2-enter-the-fray-harris-clueless-questions-about-the-1547232312-htmlstory.htmlTo the extent that the rust belt, particularly the working-class and lower-middle-class suburbs of Chicago, Detroit, and Milwaukee, are still largely Catholic (to say nothing of outlying areas), and that the highest voting demographic is people aged 60-80, Biden is a better fit than Harris. Many of these voters are members of or at least sympathetic to the Knights of Columbus organization; as for my Macomb County hometown in the 1990s, mentioning one's K of C membership was customary for state office candidates of both major parties.
None of this is to say that Harris is an inferior candidate, or that she can't win, or that she wouldn't do remarkably well with certain demographics (perhaps enough to swing AZ, for instance). But her candidacy, even if successful, would likely rest on strength elsewhere than the rust belt.