Nice post, I was just discussing with someone about him, and was on his Senate page an hour ago.
I think he could run a good campaign, if he gets more name recognation. He's charasmatic and attractive, and has a solid conservative record. However, he doesn't come across as a wacko conservative like some. With a more moderate person as his VP (Gregg, Lingle, Hutchison, Pataki) he could do pretty well against Obama.
As to your question, I also think he'll run, but mainly to set himself up to be nominated for VP and/or 2016.
He was elected at the same time as Obama was and the interview said he is a "giant killer" or something since he took down Tom Daschle. I think he could definitely run and do well in 2012, but I'd think he'd do better in 2016.