Perhaps, although Northrup held on for a long time. Be that as it may, out of curiosity, because it was so easy to calculate, based on the 2012 numbers, the PVI was - you guessed it - 0.0% on the button. Well it was 0.1% Pub, but given that one must excise about 5 or so hyper Pub precincts from either Oldham or Bullitt counties, I figure it's at absolute zero. So it does seem that in 10 or 20 years, it would indeed take a talented Pub to win it.
Northup was kind of a fluke. She won in 1996 and was lucky to not have a really bad GOP year until she finally lost in 2006.