I think that, if the climate is good enough, the Democrats can actually gain seats (though they'd be due for a loss in either 2018 or 2024); win MA and NV, lose ND while narrowly holding on with Ben Nelson due to a rough GOP primary.
That would be nearly impossible. It's one thing for the 2010 map being difficult for Republican gains, but Democrats have over 20 seats to defend to the Republicans 9. Republicans are a shoo in to at least gain 2 seats with all the opportunities they have this time around.