No, because it was economically stupid after the Mexican War.
By 1850, good mechanical cotton harvesters had been invented. If the wealthiest slaveholders had been good businessmen, they would have bought the harvesters, kept a minimum of field slaves to tend to the machines, and hired out the rest of the slaves out as corvees or industrial labor. They could have monopolized cotton growing and manufacture in one sitting, instead of shipping their crops 3000 miles off to Britain for spinning, etc.
The small cottongrowers could have scraped together enough money to buy one harvester for use among the group (like midwestern farmers had with the wheat threshers, or European peasants with the steel plow). During harvest time, the small farmers would share the machine and use their individual slaves as value-added labor in the local town.
Bingo.