Ironically, Casey losing might actually be a blessing: it would give him the perfect excuse to run for Governor in 2014. Of course, many within the party would be opposed after he lost what was seen as a safe Senate seat. Imagine if his loss ended up costing the Dems the Senate! And the usual suspects (more liberal Dems) would be opposed to him regardless of his 2012 performance.
I may go to PA in 2014 to work for whoever runs against Corbett (my primary choice is Sestak but we will see) If Casey runs and wins the nomination after losing such a race though I will not go.