Unless something changes, doesn't seem like R's have a good chance at picking this one up. This was supposed to be one of the likelier pickups after the red state democrats. Although +10 isn't too bad, still some work needs to be done to be seriously considered on the list of possible republican pickups.
Which is why we really can't predict anything about 2016 anywhere. In 2010 it looked like Shaheen (and whoever Lynch's successor turned out to be) were in serious danger because of the wave. Look what happened in 2012. Ayotte could be strongly bolstered for reelection in the same way she was.
