District polling is not a reliable thing (sorry to sound like a stuck record). But obviously this is a vulnerable district. Maybe Barrow loses this time; maybe not. If he does I suspect he'll have another crack at the seat in two years anyway...
Doubtful -it would be much harder for John Barrow to win his district back as a challenger than as an incumbent.
If anything, he would be more likely to seek a statewide office. Especially given Georgia is slowly trending towards the Democrats while his district is not.