I'd rather reject some quite unknown city in, to use Mr. Simfan's words, the "rural hinterland". Given there is quite a number of better known, still quite centrally-lying, bigger and maybe also more historic cities - Bogota, Caracas, Quito, Lima, La Paz, Santiago, Buenos Aires, São Paulo, Rio de Janeiro, Ascension, Montevideo; to name just a few.
I'd far more prefer La Paz or Buenos Aires; Rio de Janeiro being quite interesting as well.
Well I wasn't really giving a preference for any place in particular, but just pointing out that we can spread out around the place.