Open seat with a relatively moderate, populist Democrat (Campbell) favored to secure 1 spot in the runoff. John Edwards won by a pretty big margin with the same campaign strategy.
Does the likely Republican contender have his own baggage and last minute scandals too? I don't think it is fair to say that JBE won the race without significant help from Vitter's self-inflicted issues. Other LA Republicans won comfortably statewide in 2015, so the idea of a backlash against the GOP doesn't exactly hold up.