-Things didn't change for Hillary as much as she changed them. She could have run the same campaign she did in 2008 and beaten Trump.
How things changed is also irrelevant. Her husband's record, the massive mistakes she made between 2009-2013, her weaknesses as a campaigner that prevented her from rising above that stuff, and tying herself to an administration that in some regions wasn't as respected as Obama himself
(it didn't help that Obama was pushing TPP while she was running) all contributed to her failure to win.
You could try and argue that if she ran the same campaign, she'd have won, but running a different campaign may have also weakened her support among the constituencies her actual campaign meant to target with no guarantee she'd make up enough to win from others. And all of this again ignores the fact that Hillary Clinton had numerous problems
(as I listed above) that were wholly separate from a campaign strategy she was capable of carrying out. For instance, she can come out strong against TPP and pro-building up manufacturing yet the people she is after don't believe her because she has created a thick layer of distrust to makes her campaign message meaningless - particularly against an opponent who effectively made part of his campaign about her own character deficits.
So yes, I'd say Bill's pro-trade and criminal justice record combined with the negative effects of her tenure as SoS were unique.