What is the likelihood that, as in 2012, Democratic House candidates win the national popular vote, but fail to win a majority of the seats?
I'd say there's about a 54% chance that Dems win the popular vote and the House, a 45% chance that Democrats win the popular vote but not the House, and a 1% chance that Republicans win the popular vote and the House.
I can't see Jim Cooper sabotaging Democrats' House majority just because he has an axe to grind.
I don't think Cooper et. al would vote for a Republican, but they could definitely unseat Pelosi as the Democratic leader and/or force her to make policy promises. A similar situation happened in 1923 with progressive Republicans and Speaker Fredrick Gillett.