South Park is a really disgusting mean spirited show that has had a negative impact on American culture. They say they go after everyone, but their misanthropy is inherently right-wing. It would say it is more like the Fox News of TV cartoons. They both started at around the same time. Fox News (October 1996), South Park (March 1997).
They've backed off on the right-wing stuff since 2016 for obvious reasons. They even had an "apology" episode to Al Gore last year where they admitted global warming is real.
I don't know, people have been defending that show for the last 22+ years and here I am just waiting for it to end.