When did malaria stop being an issue in first-world countries?

[darklordoftech]

It was an issue when Jamestown was first established, but I don’t hear about malaria being an issue in Virginia today.

[The Mikado]

Malaria was pretty deadly in the US through the 19th and into the early 20th centuries in states on the Gulf Coast. Wetland draining in the 19th/early 20th lessened its impact, and massive chemical pesticide campaigns sgainst mosquitoes in the mid 20th century finished the job.

[darklordoftech]

Wetland draining

Is there where Trump got “drain the swamp” from?

[dead0man]

DDT did a lot of the work.  From the Wiki on the National Malaria Eradication Program

During the CDC's first few years, more than 6,500,000 homes were sprayed with the insecticide DDT. DDT was applied to the interior surfaces of rural homes or entire premises in counties where malaria was reported to have been prevalent in recent years. In addition, wetland drainage, removal of mosquito breeding sites, and DDT spraying (occasionally from aircraft) were all pursued. In 1947, some 15,000 malaria cases were reported. By the end of 1949, over 4,650,000 housespray applications had been made and the United States was declared free of malaria as a significant public health problem. By 1950, only 2,000 cases were reported. By 1951, malaria was considered eliminated altogether from the country and the CDC gradually withdrew from active participation in the operational phases of the program, shifting its interest to surveillance. In 1952, CDC participation in eradication operations ceased altogether.

it's still used in Africa and India to fight disease.

[Orser67]

To add to the other two answers, the development and use of quinine in the 19th century was also a pretty big deal. My understanding is that quinine played a major role in allowing Europeans to conquer Africa, rather than just having outposts on the coast.

[Meclazine for Israel]

To add to the other two answers, the development and use of quinine in the 19th century was also a pretty big deal. My understanding is that quinine played a major role in allowing Europeans to conquer Africa, rather than just having outposts on the coast.

I got treated in Africa for malaria in 2013.

The drug - Quinine.

They have cycled through all the drugs because of parasitic resistance, and stsrted again, because modern malaria has no resistance to the older drugs.

Malaria is very treatable, so it only really exists in poor countries near the equator.