I feel like for a lot of these, it depends upon how they present.
A good example would be Obama 2008 - when he ran, he defied many of the negative stereotypes about black people and was able to win. I think if he was a black man that fit into certain stereotypes, even physically, he may have had a harder time (i.e. darker skin, an urban African-American dialect, ect).
Same goes for gay/bi folks. I think America could theoretically elect a gay President like Pete Buttigieg in 2024, however, a gay man who presents as more submissive and feminine, defying many traditional gender roles would probably not be able to win.
I think for a lot of these groups, individual members could be elected, but members who fit into certain subsets of these groups wouldn't be.
The major issue for Gay candidates is actually the polarization. The best for one would be Blue/Purple state Republican or a Red State Democrat, but a gay male would have to be a notch or two to the right of a heterosexual one in a similar fashion to how Obama initially signaled that way.
The best trajectory would probably be a Gay Lee Zeldin. Gay, ultra Pro-Cop(which in the current climate would mean major fights with Pride groups which have seen a total ACAB takeover) immigration and whose credit for "ending anarchy" in a blue state would get him credit in the right. At the same time being in a blue state would get them forgiven some stuff.
Also if married with kids they would probably need a Sister Souhjah moment of stating how uncomfortable they were with sex in schools and give a heartfelt interview in favor of parental rights. That they would likely be hated by activists and the feeling would be mutual would aid them
This person probably couldn't win the nomination. They could potentially stumble into the Vice Presidency however